It’s Not About The Number Of OspCs, It’s About Having Proven Protection.
Only Nobivac® Lyme is proven to protect dogs by inducing borreliacidal antibodies to both OspA and OspC and is the first licensed vaccine demonstrated effective against subclinical arthritis.1,5
Talk to Your Clients About Lyme Disease
Transmission of Lyme
Lyme disease is transmitted by Ixodes spp. ticks, commonly called deer ticks. The ticks carry the bacterial cause of Lyme disease, Borrelia burgdorferi
After attaching to a dog, a tick takes a blood meal which stimulates the B. burgdorferi, in the midgut of the tick to change their outer surface protein from Osp A to Osp C. This outer surface protein change enables the bacterium to move to the tick’s salivary glands and from there it can be injected into the dog’s bloodstream.
Once in the bloodstream the organism is carried to multiple locations, including the joints. Dogs may still appear asymptomatic despite disease presence.
Let’s Talk Lyme Disease Facts:
According to the CDC, there’s an increase in ticks and a massive increase in tick related diseases, with the number of reported tickborne diseases more than doubling in the last 13 years.81
- Tickborne diseases are on the rise and prevention should be on everyone’s mind
- Ticks that can transmit Lyme disease have expanded their geographic range and are now being found in places they weren’t seen 20 years ago82
- The number of counties in the US considered to be high risk for Lyme disease has increased by 320% since the 1990s82
- CAPC data shows that dogs are being exposed to Lyme disease in areas nationwide outside of those traditionally considered to be endemic of Lyme disease54
- Approximately 75% of unvaccinated dogs in endemic areas will eventually test positive for Lyme disease55
- The best way to protect dogs is year-round flea and tick control and vaccinating those dogs that visit or live in endemic areas56
U.S. Canine Lyme Disease Prevalence83
Lyme Disease Risks
Lyme Disease Presents Multiple Threats to Your Patients
Dogs at Risk
- Dogs that live in or will be travelling to states with high or moderately high Lyme disease prevalence and populations of Ixodes ticks are at risk for infection.
- Labrador Retrievers and Golden Retrievers are at greater risk for developing Lyme disease nephritis.58,59
Infection Factors
- Infection rates of the vectors vary by region and season and can be as high as 50% in adult ticks.84
- After tick attachment, >24 hrs elapse before the first organisms are transmitted into the host’s skin.84
- Encourage your clients to perform tick checks anytime their dog returns from the outdoors to minimize attachment time.
Morbidity Threats
- While arthritis is the most common clinical manifestation of Lyme disease, Lyme nephritis can also develop and is generally fatal.
It’s About Stimulating Borreliacidal Antibodies to Both OspA and OspC
With Incidence and risk of Lyme disease on the rise, give your patients the proven protection of Nobivac® Lyme.54 Only Nobivac® Lyme is proven to protect dogs by inducing borreliacidal antibodies to both OspA and OspC.80
Targeting the Conserved Region
Nobivac® Lyme induces antibody response that produces proven protection
- Nobivac® Lyme uses patented technology to target the conserved region of OspC that is common to all Borrelia species expressing OspC add reference 1,5.
- Dogs vaccinated with Nobivac® Lyme will form borreliacidal antibodies which will eliminate any strain of Borrelia burgdorferi that expresses OspC add references 1,5,80.
- Not all antibodies are the same, only Nobivac® Lyme actually stimulated OspC borreliacidal (killing) antibodies.1,80
Borreliacidal Antibodies
Not all antibodies are the same. Borreliacidal kills quickly; opsonizing marks for destruction later.
Exceptional Efficacy Due to Double Layer Protection
The borreliacidal antibodies induced by Nobivac® Lyme were shown to be highly effective in killing B. burgdorferi and preventing infection5
Vaccine Development That Provides Comprehensive Protection.1
- Proven safe and well tolerated in a field safety trial of more than 600 dogs
- 99.3% reaction-free
- Since 2009, Nobivac® Lyme has been safely administered to over 4 million dogs
References:
1. Data on file, Merck Animal Health.
5. LaFleur RL, Dant JC, Wasmoen TL, et al. Bacterin that induces anti-OspA and anti-OspC borreliacidal antibodies provides a high level of protection against canine Lyme disease. Clin Vaccine lmmunol. 2009;16(2):253-259.
54.https://wwwnc.cdc.gov/eid/article/21/8/pdfs/14-1878.pdf. Accessed July 26, 2018.
55.http://www.petsandparasites.org/parasite-prevalence-maps#2018/all/lyme-disease/dog/united-states/. Accessed July 26, 2018.
56. AAHA Canine Vaccination Guidelines (Revised 2017). https://www.aaha.org/guidelines/canine_vaccination_guidelines/practice_vaccination.aspx. Accessed July 26, 2018.
58. Goldstein RE. Borrelia burgdorferi, Lyme nephritis and total Lyme disease management. In: North American Veterinary Conference, eds. NAVC Proceedings 2006. Ithaca, NY: International Veterinary Information Service; 2006. Available at: http://www.ivis.org/proceedings/navc/2006/SAE/359.asp?LA=1. Accessed February 25, 2013.
59. Huston L. Canine Lyme disease nephritis: a rare fatal complication of Lyme disease in dogs. Available at: http://www.suite101.com/content/canine-lyme-disease-nephritis-a100756. Accessed February 25, 2013.
80. Dant JC, LaFleur RL, Callister SM, Stahl M, et al. Ability of antibodies induced by canine Lyme disease vaccines to kill viable spirochetes. ISCAID Symposium Proceedings, Oct 2016, Bristol, UK.
81. Dogs continue to be at an elevated risk of heartworm disease and lyme disease in 2018. http://www.petsandparasites.org/expert-insights/dogs-continue-tobe-at-an-elevated-risk-of-heartworm-disease-and-lyme-disea/. Accessed August 2, 2018.
82.https://www.cdc.gov/media/dpk/diseases-and-conditions/lyme-disease/index.html. Accessed July 26, 2018.
83. Companion Animal Parasite Council. http://www.petsandparasites.org/parasite-prevalence-maps/#2018/all/lyme-disease/dog/united-states/. Accessed September 29, 2018.
84. Overview Of Lyme Borreliosis – Generalized Conditions https://www.merckvetmanual.com/generalized-conditions/lyme-borreliosis/overview-of-lyme-borreliosis. Accessed August 3, 2019.
